交易须知
kisspeptin-10 trifluoroacetate产品活性：kisspeptin-10是具有全部生物活性的kisspeptin最短多肽段，它是一种有效的 gpr54 内源性配体。
研究领域：others
作用靶点：others
in vitro: kisspeptin-10 is the minimal kisspeptin sequence with full intrinsic bioactivity. kisspeptins are a family of peptides encoded by the kiss1 gene and are the natural ligands of the orphan g protein-coupled receptor gpr54. kisspeptins act as the principal positive regulator of the reproductive axis by directly stimulating gonadotropin-releasing hormone (gnrh) neuron activity. kisspeptin-10 also has a direct stimulating effect on luteinizing hormone (lh) secretion in bovine anterior pituitary (ap) cells. different concentrations of kisspeptin-10 have distinct effects on migration and proliferation of endothelial cells. migration and proliferation of endothelial cells are increased at lower concentration of kisspeptin-10 specially at 100 nm while higher concentration reduced both migration and proliferation.
in vivo: intravenous infusion of kisspeptin-10 (7.5, 35, and 100 nm) induces a dose-dependent increase in lh secretion. the stimulatory effect of kisspeptin-10 (100 n nm) on lh secretion is blocked by the gnrh antagonist cetrorelix, precluding a singular action on gonadotropes. kisspeptin-10 inhibits angiogenesis in vivo. kp-10 inhibits tumor growth in scid mice xenografted with human prostate cancer cells (pc-3) through inhibiting tumor angiogenesis.
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